IMMUNE CONTROL OF HIV-1 INFECTION AFTER THERAPY INTERRUPTION: IMMEDIATE VERSUS DEFERRED ANTIRETROVIRAL THERAPY

Immune control of HIV-1 infection after therapy interruption: immediate versus deferred antiretroviral therapy

Abstract Background The optimal stage for initiating antiretroviral therapies in HIV-1 bearing patients is still a matter of debate.Methods We present computer simulations of HIV-1 infection aimed at identifying the pro et contra of immediate as compared to deferred Highly Active Antiretroviral Therapy (HAART).Results Our simulations highlight that

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Open Partial Horizontal Laryngectomy as a Conservative Salvage Treatment for Laser-Recurrent Laryngeal Cancer: A Multi-Institutional Series

Early-stage laryngeal cancer (T1-T2) is commonly treated with organ-preserving techniques such as transoral laser microsurgery (TOLMS) or radiation therapy (RT), both providing comparable oncological outcomes but differing in functional results.Local recurrence occurs in approximately kt-swled45ps-4a-8csa-vdim-p 10% of cases, making salvage surgery

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Consumption patterns before and during the COVID-19 pandemic among patients admitted to inpatient drug detoxification treatment: Results of two cross-sectional surveys from 2018 and 2021

BackgroundThe lockdown measures during the SARS-CoV-2 pandemic could have influenced drug consumption patterns of persons with viking g-5 drug use disorder, especially due to a reduced availability of drugs, an increased consumption of sedating substances as a coping strategy, or a shift to novel psychotropic substances (NPS) associated with an inc

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